Four people under the age of 20 are in hospital after their car crashed on the remote Tiwi Islands yesterday.
There were six people in the car when it collided with a tree, which saw significant damage with the impact.
Only two made it out with lucky escapes.
The injured patients received initial treatment from staff at Nguiu clinic, but needed further medical attention.
About 100 kilometres from the nearest hospital in Darwin, the health professionals called CareFlight - a team of doctors, paramedics and nurses specially trained to care for seriously injured people who need emergency treatment at the scene of an accident.
"The patients were transported on board two fixed wing aircraft, with two flight nurses and a doctor providing treatment during the flight for suspected spinal, head and limb injuries," a CareFlight spokesperson said.
The patients were airlifted to Royal Darwin Hospital in a stable condition.
Deputy Opposition Leader Lia Finocchiaro, said the outcomes for the injured patients could have been dire if not for the remote clinic's fast response.
"Health clinics play a critical role in delivering care to Territorians in our remote and rural areas," Ms Finocchiaro said.
"The fast response set by the Nguiu clinic highlights the importance of investing in health care in our regions."
The emergency treatment comes just days after CareFlight saved a fisherman from Tiwi's crocodile infested waters.
A fast and collaborative response from emergency services meant the local fisherman returned home uninjured just hours after he activated an emergency beacon when his small boat started filling with water.
NT Water Police Search and Rescue coordinator, Travis Edwards, said the man's quick activation of the beacon meant response was fast and the man was rescued by CareFlight in just a few short hours.
"Australia is really fortunate to have great search and rescue systems and equipment in place," he said.
"The rescue illustrates how effective these are, and how efficient they can be when safety equipment is carried and activated appropriately."
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