Police this afternoon said the 36-year-old male driver and 18-year-old female rear passenger were ejected from the vehicle and survived the vehicle roll over.

The fatal accident happened five kilometres east of Timber Creek at about 9.50pm.

Motorists are urged to take care of the accident scene.

Both the driver and the passenger were taken to the local Timber Creek health clinic and the man was airlifted to Darwin for treatment.

Traffic restrictions at this section of the Victoria Highway remain in place with one lane remaining closed for the day.

Detectives from the Major Crash Unit are investigating.

While you're with us, you can now receive updates straight to your inbox each Friday at 6am from the Katherine Times. To make sure you're up to date with all the news, sign up here.